On May 8^th, the research group led by Zhou Dawang and Chen Lanfen, professors with Innovation Center for Cell Signaling Network, State Key Laboratory of Cellular Stress Biology and School of Life Sciences, XMU, published a paper on Caner Cell, a world-leading journal on cancer research, titled “Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2”.

Researchers found out that Hippo signaling played a key role in suppressing cell ploid, and this mechanism may result in genomic instability and thus cause tumorigenesis.

The paper was mainly composed by doctoral students, Zhang Shihao, Chen Qinghua, Liu Qingxu, Li Yuxi and Sun Xiufeng, with the support of Institute of Biochemistry and Cell Biology, CAS, Albert Einstein College of Medicine in the US and Kyushu University in Japan. Corresponding authors are Prof. Zhou Dawang and Prof. Chen Lanfen.